| 12/28/80 | 80-52 | The Dr. Demento Show #80-52 - December 28, 1980
Topic: The Funny 25 of 1980 | |
| 12/28/80 | KMET-80-52 | The Dr. Demento Show (live on KMET) - December 28, 1980
Topic: Dr. Demento Funny 50 - 1980 | |
| 12/21/80 | 80-51 | The Dr. Demento Show #80-51 - December 21, 1980 | |
| 12/14/80 | 80-50 | The Dr. Demento Show #80-50 - December 14, 1980 | |
| 12/07/80 | 80-49 | The Dr. Demento Show #80-49 - December 7, 1980
Topic: 10th Anniversary | |
| 11/30/80 | 80-48 | The Dr. Demento Show #80-48 - November 30, 1980 | |
| 11/23/80 | 80-47 | The Dr. Demento Show #80-47 - November 23, 1980 | |
| 11/16/80 | 80-46 | The Dr. Demento Show #80-46 - November 16, 1980 | |
| 11/09/80 | 80-45 | The Dr. Demento Show #80-45 - November 9, 1980
Topic: Shaun Cassidy (w/ Barnes & Barnes) visit | |
| 11/02/80 | 80-44 | The Dr. Demento Show #80-44 - November 2, 1980
Topic: The Dr. Demento Election Special (1928 - 1980) | |
| 10/26/80 | 80-43 | The Dr. Demento Show #80-43 - October 26, 1980 | |
| 10/19/80 | 80-42 | The Dr. Demento Show #80-42 - October 19, 1980 | |
| 10/19/80 | KMET-08-42 | The Dr. Demento Show (live on KMET) - October 19, 1980 (6p-10p)
Topic: Special guest Boogie Boy (infant that appears at the end of every Devo concert) | |
| 10/12/80 | 80-41 | The Dr. Demento Show #80-41 - October 12, 1980 | |
| 10/05/80 | 80-40 | The Dr. Demento Show #80-40 - October 5, 1980 | |
| 09/28/80 | 80-39 | The Dr. Demento Show #80-39 - September 28, 1980 | |
| 09/28/80 | 80-39_KMET | The Dr. Demento Show (live on KMET) - September 28, 1980 (6p-10p)
Topic: Football/Jewish humor through the ages/a very special guest | |
| 09/21/80 | 80-38 | The Dr. Demento Show #80-38 - September 21, 1980 | |
| 09/14/80 | 80-37 | The Dr. Demento Show #80-37 - September 14, 1980 | |
| 09/14/80 | KMET-80-29 | The Dr. Demento Show (live on KMET) - September 14, 1980 (6p-10p) | |
| 09/07/80 | 80-36 | The Dr. Demento Show #80-36 - September 7, 1980 | |
| 08/31/80 | 80-35 | The Dr. Demento Show #80-35 - August 31, 1980
Topic: Barnes & Barnes Interview | |
| 08/24/80 | 80-34 | The Dr. Demento Show #80-34 - August 24, 1980
Topic: Scatman Crothers interview | |
| 08/17/80 | 80-33 | The Dr. Demento Show #80-33 - August 17, 1980
Topic: co-hosted by Tonio K [except segment 1 and Funny Five] | |
| 08/10/80 | 80-32 | The Dr. Demento Show #80-32 - August 10, 1980
Topic: Louis Jordan; John Landis co-hosting (with some intros by The Blues Brothers - John Belushi & Dan Aykroyd) | |
| 08/03/80 | 80-31 | The Dr. Demento Show #80-31 - August 3, 1980 | |
| 07/27/80 | 80-30 | The Dr. Demento Show #80-30 - July 27, 1980
Topic: baseball | |
| 07/20/80 | 80-29 | The Dr. Demento Show #80-29 - July 20, 1980
Topic: story time | |
| 07/13/80 | 80-28 | The Dr. Demento Show #80-28 - July 13, 1980
Topic: Interview with Cheech & Chong | |
| 07/06/80 | 80-27 | The Dr. Demento Show #80-27 - July 6, 1980
Topic: war | |
| 06/29/80 | 80-26 | The Dr. Demento Show #80-26 - June 29, 1980 | |
| 06/22/80 | 80-25 | The Dr. Demento Show #80-25 - June 22, 1980 | |
| 06/15/80 | 80-24 | The Dr. Demento Show #80-24 - June 15, 1980
Topic: 50 years of Dementia - Part II | |
| 06/08/80 | 80-23 | The Dr. Demento Show #80-23 - June 8, 1980
Topic: 50 Years of Dementia - Part 1 | |
| 06/01/80 | 80-22 | The Dr. Demento Show #80-22 - June 1, 1980
Topic: beans | |
| 05/25/80 | 80-21 | The Dr. Demento Show #80-21 - May 25, 1980 | |
| 05/18/80 | 80-20 | The Dr. Demento Show #80-20 - May 18, 1980 | |
| 05/11/80 | 80-19 | The Dr. Demento Show #80-19 - May 11, 1980
Topic: off-key singing; Frank Zappa & The Mothers | |
| 05/04/80 | 80-18 | The Dr. Demento Show #80-18 - May 4, 1980 | |
| 04/27/80 | 80-17 | The Dr. Demento Show #80-17 - April 27, 1980 | |
| 04/20/80 | 80-16 | The Dr. Demento Show #80-16 - April 20, 1980 | |
| 04/13/80 | 80-15 | The Dr. Demento Show #80-15 - April 13, 1980 | |
| 04/06/80 | 80-14 | The Dr. Demento Show #80-14 - April 6, 1980 | |
| 03/30/80 | 80-13 | The Dr. Demento Show #80-13 - March 30, 1980 | |
| 03/23/80 | 80-12 | The Dr. Demento Show #80-12 - March 23, 1980 | |
| 03/16/80 | 80-11 | The Dr. Demento Show #80-11 - March 16, 1980 | |
| 03/09/80 | 80-10 | The Dr. Demento Show #80-10 - March 9, 1980 | |
| 03/02/80 | 80-09 | The Dr. Demento Show #80-09 - March 2, 1980 | |
| 02/24/80 | 80-08 | The Dr. Demento Show #80-08 - February 24, 1980 | |
| 02/17/80 | 80-07 | The Dr. Demento Show #80-07 - February 17, 1980 | |
| 02/10/80 | 80-06 | The Dr. Demento Show #80-06 - February 10, 1980 | |
| 02/03/80 | 80-05 | The Dr. Demento Show #80-05 - February 3, 1980 | |
| 01/27/80 | 80-04 | The Dr. Demento Show #80-04 - January 27, 1980 | |
| 01/20/80 | 80-03 | The Dr. Demento Show #80-03 - January 20, 1980 | |
| 01/13/80 | 80-02 | The Dr. Demento Show #80-02 - January 13, 1980 | |
| 01/06/80 | 80-01 | The Dr. Demento Show #80-01 - January 6, 1980 | |